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Koji Nakayama Selected Research

Gingipain Cysteine Endopeptidases

1/2022Porphyromonas gingivalis Gingipains Induce Cyclooxygenase-2 Expression and Prostaglandin E2 Production via ERK1/2-Activated AP-1 (c-Jun/c-Fos) and IKK/NF-κB p65 Cascades.
10/2020PorM, a core component of bacterial type IX secretion system, forms a dimer with a unique kinked-rod shape.
1/2016Structural Insights into the PorK and PorN Components of the Porphyromonas gingivalis Type IX Secretion System.
6/2008Determination of active site of lysine-specific cysteine proteinase (Lys-gingipain) by use of a Porphyromonas gingivalis plasmid system.
4/2008Dual regulation of interleukin-8 production in human oral epithelial cells upon stimulation with gingipains from Porphyromonas gingivalis.
11/2005Arginine-specific gingipains from Porphyromonas gingivalis stimulate production of hepatocyte growth factor (scatter factor) through protease-activated receptors in human gingival fibroblasts in culture.
11/2004Roles of Arg- and Lys-gingipains in coaggregation of Porphyromonas gingivalis: identification of its responsible molecules in translation products of rgpA, kgp, and hagA genes.
8/2003Effect of inactivation of the Arg- and/or Lys-gingipain gene on selected virulence and physiological properties of Porphyromonas gingivalis.

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Koji Nakayama Research Topics

Disease

4Periodontitis
01/2022 - 08/2003
4Infections
10/2020 - 03/2004
4Chronic Periodontitis
03/2011 - 08/2004
3Inflammation (Inflammations)
01/2022 - 04/2008
3Periodontal Diseases (Periodontal Disease)
10/2020 - 04/2008
2Hemolysis
03/2010 - 08/2003
2Bone Resorption
03/2004 - 09/2003
1Arthritis (Polyarthritis)
10/2020
1Experimental Arthritis
10/2020
1Alveolar Bone Loss
10/2020
1Malignant Mesothelioma
02/2019
1Adenocarcinoma of Lung
02/2019
1Wounds and Injuries (Trauma)
03/2011
1Carcinogenesis
11/2009
1Invasive Fungal Infections
01/2006
1Bacterial Infections (Bacterial Infection)
11/2005
1Hypersensitivity (Allergy)
03/2005
1Peri-Implantitis
01/2005
1Endocarditis
11/2004
1Aortic Valve Stenosis (Aortic Stenosis)
11/2004
1Aortic Valve Insufficiency (Aortic Regurgitation)
11/2004
1Starvation
05/2000

Drug/Important Bio-Agent (IBA)

8Gingipain Cysteine EndopeptidasesIBA
01/2022 - 08/2003
5Virulence Factors (Pathogenicity Factors)IBA
10/2020 - 11/2004
4Cysteine Proteases (Cysteine Protease)IBA
06/2008 - 03/2004
3Proteins (Proteins, Gene)FDA Link
10/2020 - 11/2005
3Peptide Hydrolases (Proteases)FDA Link
11/2005 - 08/2003
2Interleukin-6 (Interleukin 6)IBA
01/2022 - 10/2020
2Biomarkers (Surrogate Marker)IBA
02/2019 - 11/2009
2Heme (Haem)IBA
03/2011 - 03/2010
2CytokinesIBA
11/2005 - 03/2004
2LipopolysaccharidesIBA
04/2004 - 03/2004
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
01/2022
1Dinoprostone (PGE2)FDA Link
01/2022
1Protein-Arginine DeiminasesIBA
10/2020
1laminaranIBA
10/2020
1Calbindin 2IBA
02/2019
1TenascinIBA
02/2019
1InflammasomesIBA
12/2018
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
02/2015
1SesquiterpenesIBA
03/2011
1(Z)-3-hexen-1-yl acetateIBA
03/2011
13-hexenalIBA
03/2011
1Lysine (L-Lysine)FDA Link
06/2008
1Interleukin-8 (Interleukin 8)IBA
04/2008
1Anti-Bacterial Agents (Antibiotics)IBA
01/2006
1Amphotericin B (Amphotericin)FDA LinkGeneric
01/2006
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
11/2005
1DiamideIBA
03/2005
1Metronidazole (Metric)FDA LinkGeneric
03/2005
1Mitomycin (Mitomycin-C)FDA LinkGeneric
03/2005
1titanium dioxide (Titania)FDA Link
01/2005
1Macrophage Colony-Stimulating FactorIBA
04/2004
1Transcription Factor AP-1 (Transcription Factor AP 1)IBA
03/2004
1Interleukin-4 (Interleukin 4)IBA
09/2003
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2003
1InterleukinsIBA
09/2003
1Amino AcidsFDA Link
08/2003
1Ferritins (Ferritin)IBA
05/2000
1Transferrin (beta 2 Transferrin)IBA
05/2000
1IronIBA
05/2000

Therapy/Procedure

1Transjugular Intrahepatic Portasystemic Shunt
11/2004